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Dapoxetine verzögert nachhaltig den ersten Samenerguss. Inadequate penetration of the infection site is one of the principal factors related to failure of antibacterial therapy. The term “substituted tetracycline compound” is intended to include compounds which are structurally related to tetracycline and which bind to the Tet repressor with a K a of at least about 10 6 M −1?